Endocrine Abstracts

Food restriction (FR) of mothers during the perinatal period, can lead to disorders in emotional behaviors at offspring. GLP-1 may play a role in the regulation of anxiety-like behavior in rodents. The aim of this study was to asses if Liraglutide (a GLP-1 receptor agonist; LIR) given to pregnant rats may prevent the deleterious effects of FR in the anxiety-like behavior in pups at 21 days and two months of age males.Twenty-five pregnant Sprague-Dawley r...

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease characterized by excessive matrix deposition that disrupts the normal alveolar architecture and lung physiology. Glucagon-like peptide 1 (GLP1) is a gut-produced hormone with insulinotropic effects. GLP1 receptor is expressed in the lung where it is implicated in the synthesis of the protein (SPs) and lipid fractions of the surfactant. We have previously shown that the GLP1 receptor agonist, l...